This site is intended for u.s. audiences
This site is intended for u.s. audiences
Learn more about MPS and find out how to get involved in raising awareness
Not all people with Hunter syndrome are affected by the disease in exactly the same way; the type and severity of symptoms, age that symptoms appear, and the rate of symptom progression all vary widely.
Developmental
delays
Speech
delays
Ear infections
Hearing loss
Cardiovascular
complications
Enlarged liver
and spleen
Respiratory
problems
Joint
stiffness
Curled
fingers
Non-neuropathic
Neuropathic
Hunter syndrome was traditionally categorized into two distinct types, severe and attenuated (now often labeled neuropathic and non-neuropathic), based on the degree of cognitive impairment involved. The severe type was defined by the presence of neurological symptoms alongside physical symptoms, all of which generally become apparent between 2 and 4 years of age. For the attenuated type, minimal cognitive impairment is involved and symptoms may only present in late childhood or early adolescence. However, due to the highly variable nature of Hunter syndrome and variety of presentation between these two types, Hunter syndrome can now be better understood as a spectrum of severity.
